Wat Si Mongkhon Tai is the temple where Mukdahan's ancient and most revered image of Buddha is enshrined. It is situated in town on the bank of Mekhong River near the immigration check-point. Within its compound, there are shops selling souvenirs and products from Laos. Boat service is available at the nearby pier for sightseeing along the Mekhong River. To cross the border to Laos, tourists are required to hold passport visaed by the Embassy of the Lao P.D.R. in Bangkok

Luang Pho Yai is a Buddha image in the gesture of giving the First Sermon seated on a hilltop within the precincts of Wat Phu Dan Tae Wat Phuttho Thammatharo. The Wat is accessible by Highway 212, a distance of 33 kilometers from the province via Amphoe Nikhom Kham Soi.

Phu Mu Forest Park is located on Highway 212 with a turn between km. 128 -129. Phu Mu is a low hill topped with a large plateau in Amphoe Nikhom Soi. The park is 353 meters above sea level and covers an area of about 4 square kilometers. It was established as a park area in 1980. Phu Mu was once home of wild boars but now is a location from where a wide view of Mukdahan can be appreciated.

Mukdahan National Park with an office situated on Mukdahan-Don Tan route with a right turn between Km. 14 -15, the park was established in December 1984 and covers a total area of some 52 square kilometers including Phu Mano, Phu Chomp Nang, Phu Chom Si, Phu Mak Rang, Phu Kham Mak Mi, Phu Tham Phra, Phu Pha Thoep, Phu Nang Hong, and Phu Lak Se, Most of the area is covered with Dipterocarps Forests and Mixed Deciduous Forests. Attractions in the park are strangely shaped rocks and colourful wild flowers in early winter.

Phu Sa Dok Bua National Park is about 50 kms. from town along the Don Tan-Loeng Nok Tha route. Tourist spots include rock paintings at Phu Pha Taem, scenic spots on high cliffs, and wild flowers blooming all around towards the end of the rainy season.